One indicator of a success organizational performance are targets, vision, and mission of the company achieved. Organizational culture measurement is one of the important things that affect organizational performance in the company. Organizational culture also supports the formation of company characteristics which also affect the achievement of company targets. The study of organizational culture was conducted at PT Telkom Indonesia Regional V to test how much the hypothesis of each cultural dimension influence organizational performance based on the theory of hofstede and other cultural variables. This research is based on changes in business processes and organizational members (millennial) followed by adjustments to organizational culture. The variables tested in this study are organizational Culture, transformational leadership, individual innovativeness and flexibility, job satisfaction, organizational citizenship behavior, and organizational performance. Measurement of organizational culture is carried out using the Structural Equation Model (SEM) method which supports statistical data processing to visualize the hypothesized relationship between variables simultaneously. The expected output from this research is a form of a study that shows how significant the influence of each cultural variable on organizational performance. The results of the hypothesis test show that H1, H2, H4, and H5 are accepted. Meanwhile, H3, H6, H7, and H8 were rejected because the t-value < 1.96. From that results can be used for a good reference for the employee development process and policy establishment for the company.