TY - JOUR
T1 - Supercritical anti-solvent micronization of marigold-derived lutein dissolved in dichloromethane and ethanol
AU - Boonnoun, Panatpong
AU - Nerome, Hazuki
AU - Machmudah, Siti
AU - Goto, Motonobu
AU - Shotipruk, Artiwan
N1 - Funding Information:
The authors greatly appreciate Thailand Research Fund (TRF) , the Integrated Innovation Academic Center: IIAC Chulalongkorn University Centenary Academic Development Project , and the Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission ( FW644A ) for financial support.
PY - 2013
Y1 - 2013
N2 - This work aims to study supercritical anti-solvent (SAS) micronization of lutein derived from marigold flowers. Lutein solution in dichloromethane (DCM) or ethanol was atomized into the stream of supercritical carbon dioxide (SC-CO2) through a concentric nozzle in a pressurized vessel. The effects of pressure and SC-CO2 flow rate on morphology, mean particle size (MPS) and particle size distribution (PSD) were investigated. The reduction in lutein MPS from 202.3 μm of unprocessed lutein to 1.58 μm and 902 nm could be achieved by SAS micronization using DCM and ethanol, respectively. In both solvent systems, no significant effects of pressure and SC-CO2 flow rate on particle morphology were observed. However, pressure was found to have a significant effect on MPS and PSDs of lutein particles.
AB - This work aims to study supercritical anti-solvent (SAS) micronization of lutein derived from marigold flowers. Lutein solution in dichloromethane (DCM) or ethanol was atomized into the stream of supercritical carbon dioxide (SC-CO2) through a concentric nozzle in a pressurized vessel. The effects of pressure and SC-CO2 flow rate on morphology, mean particle size (MPS) and particle size distribution (PSD) were investigated. The reduction in lutein MPS from 202.3 μm of unprocessed lutein to 1.58 μm and 902 nm could be achieved by SAS micronization using DCM and ethanol, respectively. In both solvent systems, no significant effects of pressure and SC-CO2 flow rate on particle morphology were observed. However, pressure was found to have a significant effect on MPS and PSDs of lutein particles.
KW - Supercritical anti-solvent Micronization Lutein Marigold Supercritical fluid
UR - http://www.scopus.com/inward/record.url?scp=84875749978&partnerID=8YFLogxK
U2 - 10.1016/j.supflu.2013.02.026
DO - 10.1016/j.supflu.2013.02.026
M3 - Article
AN - SCOPUS:84875749978
SN - 0896-8446
VL - 77
SP - 103
EP - 109
JO - Journal of Supercritical Fluids
JF - Journal of Supercritical Fluids
ER -