Supercritical anti-solvent micronization of marigold-derived lutein dissolved in dichloromethane and ethanol

Panatpong Boonnoun; Hazuki Nerome; Siti Machmudah; Motonobu Goto; Artiwan Shotipruk

doi:10.1016/j.supflu.2013.02.026

Supercritical anti-solvent micronization of marigold-derived lutein dissolved in dichloromethane and ethanol

Panatpong Boonnoun, Hazuki Nerome, Siti Machmudah, Motonobu Goto, Artiwan Shotipruk^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

This work aims to study supercritical anti-solvent (SAS) micronization of lutein derived from marigold flowers. Lutein solution in dichloromethane (DCM) or ethanol was atomized into the stream of supercritical carbon dioxide (SC-CO₂) through a concentric nozzle in a pressurized vessel. The effects of pressure and SC-CO₂ flow rate on morphology, mean particle size (MPS) and particle size distribution (PSD) were investigated. The reduction in lutein MPS from 202.3 μm of unprocessed lutein to 1.58 μm and 902 nm could be achieved by SAS micronization using DCM and ethanol, respectively. In both solvent systems, no significant effects of pressure and SC-CO₂ flow rate on particle morphology were observed. However, pressure was found to have a significant effect on MPS and PSDs of lutein particles.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Journal of Supercritical Fluids
Volume	77
DOIs	https://doi.org/10.1016/j.supflu.2013.02.026
Publication status	Published - 2013
Externally published	Yes

Keywords

Supercritical anti-solvent Micronization Lutein Marigold Supercritical fluid

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10.1016/j.supflu.2013.02.026

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title = "Supercritical anti-solvent micronization of marigold-derived lutein dissolved in dichloromethane and ethanol",

abstract = "This work aims to study supercritical anti-solvent (SAS) micronization of lutein derived from marigold flowers. Lutein solution in dichloromethane (DCM) or ethanol was atomized into the stream of supercritical carbon dioxide (SC-CO2) through a concentric nozzle in a pressurized vessel. The effects of pressure and SC-CO2 flow rate on morphology, mean particle size (MPS) and particle size distribution (PSD) were investigated. The reduction in lutein MPS from 202.3 μm of unprocessed lutein to 1.58 μm and 902 nm could be achieved by SAS micronization using DCM and ethanol, respectively. In both solvent systems, no significant effects of pressure and SC-CO2 flow rate on particle morphology were observed. However, pressure was found to have a significant effect on MPS and PSDs of lutein particles.",

keywords = "Supercritical anti-solvent Micronization Lutein Marigold Supercritical fluid",

author = "Panatpong Boonnoun and Hazuki Nerome and Siti Machmudah and Motonobu Goto and Artiwan Shotipruk",

note = "Funding Information: The authors greatly appreciate Thailand Research Fund (TRF) , the Integrated Innovation Academic Center: IIAC Chulalongkorn University Centenary Academic Development Project , and the Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission ( FW644A ) for financial support.",

year = "2013",

doi = "10.1016/j.supflu.2013.02.026",

language = "English",

volume = "77",

pages = "103--109",

journal = "Journal of Supercritical Fluids",

issn = "0896-8446",

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T1 - Supercritical anti-solvent micronization of marigold-derived lutein dissolved in dichloromethane and ethanol

AU - Boonnoun, Panatpong

AU - Nerome, Hazuki

AU - Machmudah, Siti

AU - Goto, Motonobu

AU - Shotipruk, Artiwan

N1 - Funding Information: The authors greatly appreciate Thailand Research Fund (TRF) , the Integrated Innovation Academic Center: IIAC Chulalongkorn University Centenary Academic Development Project , and the Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission ( FW644A ) for financial support.

PY - 2013

Y1 - 2013

N2 - This work aims to study supercritical anti-solvent (SAS) micronization of lutein derived from marigold flowers. Lutein solution in dichloromethane (DCM) or ethanol was atomized into the stream of supercritical carbon dioxide (SC-CO2) through a concentric nozzle in a pressurized vessel. The effects of pressure and SC-CO2 flow rate on morphology, mean particle size (MPS) and particle size distribution (PSD) were investigated. The reduction in lutein MPS from 202.3 μm of unprocessed lutein to 1.58 μm and 902 nm could be achieved by SAS micronization using DCM and ethanol, respectively. In both solvent systems, no significant effects of pressure and SC-CO2 flow rate on particle morphology were observed. However, pressure was found to have a significant effect on MPS and PSDs of lutein particles.

AB - This work aims to study supercritical anti-solvent (SAS) micronization of lutein derived from marigold flowers. Lutein solution in dichloromethane (DCM) or ethanol was atomized into the stream of supercritical carbon dioxide (SC-CO2) through a concentric nozzle in a pressurized vessel. The effects of pressure and SC-CO2 flow rate on morphology, mean particle size (MPS) and particle size distribution (PSD) were investigated. The reduction in lutein MPS from 202.3 μm of unprocessed lutein to 1.58 μm and 902 nm could be achieved by SAS micronization using DCM and ethanol, respectively. In both solvent systems, no significant effects of pressure and SC-CO2 flow rate on particle morphology were observed. However, pressure was found to have a significant effect on MPS and PSDs of lutein particles.

KW - Supercritical anti-solvent Micronization Lutein Marigold Supercritical fluid

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DO - 10.1016/j.supflu.2013.02.026

M3 - Article

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SN - 0896-8446

VL - 77

SP - 103

EP - 109

JO - Journal of Supercritical Fluids

JF - Journal of Supercritical Fluids

ER -

Supercritical anti-solvent micronization of marigold-derived lutein dissolved in dichloromethane and ethanol

Abstract

Keywords

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