Abstract

The ligand 2,4,5-triphenyl-1H-imidazole (L) has been used to synthesize copper(II) complex, [Cu(L)2(H2O)2].Cl2. The complex is well characterized from various spectral and physical meausrements. Complex synthesis resulted in obtaining a green, light crystalline solid. The maximum absorbance, at 529 nm, indicated bonding had occurred within the metal-ligand that is Cu-N in region 422.38 cm-1. Cytotoxicity was tested for in complex compounds made by the method of (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide) (MTT). The value of cytotoxicity activity (CC50) of complex compounds against T74D and HeLa cells was 8.78 μg/ml, 14.46 μg/ml, respectively, indicating promising anticancer activity. The complex enhanced growth inhibition; the cells exhibited better anticancer activities in both the T74D and HeLa cell lines. Despite potent in vitro activity, this complex compound exhibited a cytotoxicity against the normal Vero cells at an effective concentration.

Original languageEnglish
Pages (from-to)4839-4843
Number of pages5
JournalBiochemical and Cellular Archives
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • 2,4,5-triphenyl-1H-imidazole
  • Anticancer
  • Complex compound
  • Copper(II)
  • HeLa cells
  • T74D cells

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