Abstract
The ligand 2,4,5-triphenyl-1H-imidazole (L) has been used to synthesize copper(II) complex, [Cu(L)2(H2O)2].Cl2. The complex is well characterized from various spectral and physical meausrements. Complex synthesis resulted in obtaining a green, light crystalline solid. The maximum absorbance, at 529 nm, indicated bonding had occurred within the metal-ligand that is Cu-N in region 422.38 cm-1. Cytotoxicity was tested for in complex compounds made by the method of (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide) (MTT). The value of cytotoxicity activity (CC50) of complex compounds against T74D and HeLa cells was 8.78 μg/ml, 14.46 μg/ml, respectively, indicating promising anticancer activity. The complex enhanced growth inhibition; the cells exhibited better anticancer activities in both the T74D and HeLa cell lines. Despite potent in vitro activity, this complex compound exhibited a cytotoxicity against the normal Vero cells at an effective concentration.
Original language | English |
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Pages (from-to) | 4839-4843 |
Number of pages | 5 |
Journal | Biochemical and Cellular Archives |
DOIs | |
Publication status | Published - 1 Dec 2019 |
Keywords
- 2,4,5-triphenyl-1H-imidazole
- Anticancer
- Complex compound
- Copper(II)
- HeLa cells
- T74D cells