Abstract

The synthesis and antitubercular activity of trisindoline (2) and benzylated trisindolines (3a-b) are reported herein. Trisindoline (2) was synthesized from isatin (1) in 97% yield, in addition benzylated trisindolines (3a-b) from 5-bromo-1-(4-nitrobenzyl)isatin (5a) and 1-benzyl-5-bromoisatin (5b) in 83% and 80% yields, respectively. Antitubercular assay showed that trisindoline (3a) has a better activity to inhibit Micobacterium tuberculosis H37Rv.

Original languageEnglish
Title of host publication3rd International Seminar on Chemistry
Subtitle of host publicationGreen Chemistry and Its Role for Sustainability
EditorsFredy Kurniawan, Yuly Kusumawati, Sri Fatmawati, Hendro Juwono, Adi Setyo Purnomo
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735417755
DOIs
Publication statusPublished - 14 Dec 2018
Event3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018 - Surabaya, Indonesia
Duration: 18 Jul 201819 Jul 2018

Publication series

NameAIP Conference Proceedings
Volume2049
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018
Country/TerritoryIndonesia
CitySurabaya
Period18/07/1819/07/18

Keywords

  • antitubercular
  • synthesis
  • trisindolines

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