Synthesis and anti-tuberculosis activity of trisindolines

Rose Malina Annuur; Dyah Ayu Titisari; Rahma Rahayu Dinarlita; Arif Fadlan; Taslim Ersam; Titik Nuryastuti; Mardi Santoso

doi:10.1063/1.5082493

Synthesis and anti-tuberculosis activity of trisindolines

Rose Malina Annuur
, Dyah Ayu Titisari
, Rahma Rahayu Dinarlita
, Arif Fadlan
, Taslim Ersam
, Titik Nuryastuti
, Mardi Santoso^*

^*Corresponding author for this work

Institut Teknologi Sepuluh Nopember
Gadjah Mada University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

13 Citations (Scopus)

Abstract

The synthesis and antitubercular activity of trisindoline (2) and benzylated trisindolines (3a-b) are reported herein. Trisindoline (2) was synthesized from isatin (1) in 97% yield, in addition benzylated trisindolines (3a-b) from 5-bromo-1-(4-nitrobenzyl)isatin (5a) and 1-benzyl-5-bromoisatin (5b) in 83% and 80% yields, respectively. Antitubercular assay showed that trisindoline (3a) has a better activity to inhibit Micobacterium tuberculosis H37Rv.

Original language	English
Title of host publication	3rd International Seminar on Chemistry
Subtitle of host publication	Green Chemistry and Its Role for Sustainability
Editors	Fredy Kurniawan, Yuly Kusumawati, Sri Fatmawati, Hendro Juwono, Adi Setyo Purnomo
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735417755
DOIs	https://doi.org/10.1063/1.5082493
Publication status	Published - 14 Dec 2018
Event	3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018 - Surabaya, Indonesia Duration: 18 Jul 2018 → 19 Jul 2018

Publication series

Name	AIP Conference Proceedings
Volume	2049
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018
Country/Territory	Indonesia
City	Surabaya
Period	18/07/18 → 19/07/18

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

antitubercular
synthesis
trisindolines

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10.1063/1.5082493

Cite this

Annuur, R. M., Titisari, D. A., Dinarlita, R. R., Fadlan, A., Ersam, T., Nuryastuti, T., & Santoso, M. (2018). Synthesis and anti-tuberculosis activity of trisindolines. In F. Kurniawan, Y. Kusumawati, S. Fatmawati, H. Juwono, & A. S. Purnomo (Eds.), 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability Article 020088 (AIP Conference Proceedings; Vol. 2049). American Institute of Physics Inc.. https://doi.org/10.1063/1.5082493

Annuur, Rose Malina ; Titisari, Dyah Ayu ; Dinarlita, Rahma Rahayu et al. / Synthesis and anti-tuberculosis activity of trisindolines. 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability. editor / Fredy Kurniawan ; Yuly Kusumawati ; Sri Fatmawati ; Hendro Juwono ; Adi Setyo Purnomo. American Institute of Physics Inc., 2018. (AIP Conference Proceedings).

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title = "Synthesis and anti-tuberculosis activity of trisindolines",

abstract = "The synthesis and antitubercular activity of trisindoline (2) and benzylated trisindolines (3a-b) are reported herein. Trisindoline (2) was synthesized from isatin (1) in 97\% yield, in addition benzylated trisindolines (3a-b) from 5-bromo-1-(4-nitrobenzyl)isatin (5a) and 1-benzyl-5-bromoisatin (5b) in 83\% and 80\% yields, respectively. Antitubercular assay showed that trisindoline (3a) has a better activity to inhibit Micobacterium tuberculosis H37Rv.",

keywords = "antitubercular, synthesis, trisindolines",

author = "Annuur, \{Rose Malina\} and Titisari, \{Dyah Ayu\} and Dinarlita, \{Rahma Rahayu\} and Arif Fadlan and Taslim Ersam and Titik Nuryastuti and Mardi Santoso",

note = "Publisher Copyright: {\textcopyright} 2018 Author(s).; 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018 ; Conference date: 18-07-2018 Through 19-07-2018",

year = "2018",

month = dec,

day = "14",

doi = "10.1063/1.5082493",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Fredy Kurniawan and Yuly Kusumawati and Sri Fatmawati and Hendro Juwono and Purnomo, \{Adi Setyo\}",

booktitle = "3rd International Seminar on Chemistry",

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Annuur, RM, Titisari, DA, Dinarlita, RR, Fadlan, A, Ersam, T, Nuryastuti, T & Santoso, M 2018, Synthesis and anti-tuberculosis activity of trisindolines. in F Kurniawan, Y Kusumawati, S Fatmawati, H Juwono & AS Purnomo (eds), 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability., 020088, AIP Conference Proceedings, vol. 2049, American Institute of Physics Inc., 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018, Surabaya, Indonesia, 18/07/18. https://doi.org/10.1063/1.5082493

Synthesis and anti-tuberculosis activity of trisindolines. / Annuur, Rose Malina; Titisari, Dyah Ayu; Dinarlita, Rahma Rahayu et al.
3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability. ed. / Fredy Kurniawan; Yuly Kusumawati; Sri Fatmawati; Hendro Juwono; Adi Setyo Purnomo. American Institute of Physics Inc., 2018. 020088 (AIP Conference Proceedings; Vol. 2049).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Synthesis and anti-tuberculosis activity of trisindolines

AU - Annuur, Rose Malina

AU - Titisari, Dyah Ayu

AU - Dinarlita, Rahma Rahayu

AU - Fadlan, Arif

AU - Ersam, Taslim

AU - Nuryastuti, Titik

AU - Santoso, Mardi

PY - 2018/12/14

Y1 - 2018/12/14

N2 - The synthesis and antitubercular activity of trisindoline (2) and benzylated trisindolines (3a-b) are reported herein. Trisindoline (2) was synthesized from isatin (1) in 97% yield, in addition benzylated trisindolines (3a-b) from 5-bromo-1-(4-nitrobenzyl)isatin (5a) and 1-benzyl-5-bromoisatin (5b) in 83% and 80% yields, respectively. Antitubercular assay showed that trisindoline (3a) has a better activity to inhibit Micobacterium tuberculosis H37Rv.

AB - The synthesis and antitubercular activity of trisindoline (2) and benzylated trisindolines (3a-b) are reported herein. Trisindoline (2) was synthesized from isatin (1) in 97% yield, in addition benzylated trisindolines (3a-b) from 5-bromo-1-(4-nitrobenzyl)isatin (5a) and 1-benzyl-5-bromoisatin (5b) in 83% and 80% yields, respectively. Antitubercular assay showed that trisindoline (3a) has a better activity to inhibit Micobacterium tuberculosis H37Rv.

KW - antitubercular

KW - synthesis

KW - trisindolines

UR - https://www.scopus.com/pages/publications/85059001985

U2 - 10.1063/1.5082493

DO - 10.1063/1.5082493

M3 - Conference contribution

AN - SCOPUS:85059001985

T3 - AIP Conference Proceedings

BT - 3rd International Seminar on Chemistry

A2 - Kurniawan, Fredy

A2 - Kusumawati, Yuly

A2 - Fatmawati, Sri

A2 - Juwono, Hendro

A2 - Purnomo, Adi Setyo

PB - American Institute of Physics Inc.

T2 - 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018

Y2 - 18 July 2018 through 19 July 2018

ER -

Annuur RM, Titisari DA, Dinarlita RR, Fadlan A, Ersam T, Nuryastuti T et al. Synthesis and anti-tuberculosis activity of trisindolines. In Kurniawan F, Kusumawati Y, Fatmawati S, Juwono H, Purnomo AS, editors, 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability. American Institute of Physics Inc. 2018. 020088. (AIP Conference Proceedings). doi: 10.1063/1.5082493

Synthesis and anti-tuberculosis activity of trisindolines

Abstract

Publication series

Conference

UN SDGs

Keywords

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