In this study, two cobalt [Co(II)] Complexes were synthesized using picolinic acid (2-pyridine carbocyclic) ligand under various pH conditions. Both Complexes were characterized using FTIR, UV-Vis, XRD, CHNS microanalysis, and thermogravimetric analysis (TGA). The Complex synthesized using metal ion: ligand mol ratio of 1:1 under pH ~2 has a molecular formula of [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O. On the other hand, the Complex synthesized using the higher ligand to metal ratio of 2 at pH ~1 has a molecular formula of [CoII (H2dipic)-(dipic)].3H2O. The [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O Complex demonstrating toxicity toward Artemia salina larvae (BSL) with the LC50 value of 5.38 ppm. Meanwhile, the [CoII (H2dipic)-(dipic)].3H2O possess an LC50 value of 8.61 ppm against the same larvae. Results showed that the Co (II)-2 Pyridine carbocyclic based Complex synthesized under acid environment demonstrating potential characteristic as anticancer cell.

Original languageEnglish
Pages (from-to)1629-1634
Number of pages6
JournalRasayan Journal of Chemistry
Issue number3
Publication statusPublished - 1 Jul 2021


  • Anticancer Compound
  • BSL Test
  • Co (II) Complexes
  • Dipicolinate Ligand
  • Polymer Complexes
  • Toxicity Test


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