Synthesis and characterization of co (Ii) pyridine-2,6-dicarboxylate complexes as anticancer compound

Fahimah Martak; Endah Mutiara; Mahbub Alwathoni; Triyanda Gunawan; Soegeng Soegijanto

doi:10.31788/RJC.2021.1435823

Synthesis and characterization of co (Ii) pyridine-2,6-dicarboxylate complexes as anticancer compound

Fahimah Martak^*
, Endah Mutiara
, Mahbub Alwathoni
, Triyanda Gunawan
, Soegeng Soegijanto

^*Corresponding author for this work

Institut Teknologi Sepuluh Nopember
Universitas Airlangga

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In this study, two cobalt [Co(II)] Complexes were synthesized using picolinic acid (2-pyridine carbocyclic) ligand under various pH conditions. Both Complexes were characterized using FTIR, UV-Vis, XRD, CHNS microanalysis, and thermogravimetric analysis (TGA). The Complex synthesized using metal ion: ligand mol ratio of 1:1 under pH ~2 has a molecular formula of [Co^II (dipic)(μ-dipic)-Co^II (H₂O)₅].2H₂O. On the other hand, the Complex synthesized using the higher ligand to metal ratio of 2 at pH ~1 has a molecular formula of [Co^II (H₂dipic)-(dipic)].3H₂O. The [Co^II (dipic)(μ-dipic)-Co^II (H₂O)₅].2H₂O Complex demonstrating toxicity toward Artemia salina larvae (BSL) with the LC₅₀ value of 5.38 ppm. Meanwhile, the [Co^II (H₂dipic)-(dipic)].3H₂O possess an LC₅₀ value of 8.61 ppm against the same larvae. Results showed that the Co (II)-2 Pyridine carbocyclic based Complex synthesized under acid environment demonstrating potential characteristic as anticancer cell.

Original language	English
Pages (from-to)	1629-1634
Number of pages	6
Journal	Rasayan Journal of Chemistry
Volume	14
Issue number	3
DOIs	https://doi.org/10.31788/RJC.2021.1435823
Publication status	Published - 1 Jul 2021

Keywords

Anticancer Compound
BSL Test
Co (II) Complexes
Dipicolinate Ligand
Polymer Complexes
Toxicity Test

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10.31788/RJC.2021.1435823

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@article{4c6eab16ea3c427cade4fd7ab3d15a70,

title = "Synthesis and characterization of co (Ii) pyridine-2,6-dicarboxylate complexes as anticancer compound",

abstract = "In this study, two cobalt [Co(II)] Complexes were synthesized using picolinic acid (2-pyridine carbocyclic) ligand under various pH conditions. Both Complexes were characterized using FTIR, UV-Vis, XRD, CHNS microanalysis, and thermogravimetric analysis (TGA). The Complex synthesized using metal ion: ligand mol ratio of 1:1 under pH \textasciitilde{}2 has a molecular formula of [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O. On the other hand, the Complex synthesized using the higher ligand to metal ratio of 2 at pH \textasciitilde{}1 has a molecular formula of [CoII (H2dipic)-(dipic)].3H2O. The [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O Complex demonstrating toxicity toward Artemia salina larvae (BSL) with the LC50 value of 5.38 ppm. Meanwhile, the [CoII (H2dipic)-(dipic)].3H2O possess an LC50 value of 8.61 ppm against the same larvae. Results showed that the Co (II)-2 Pyridine carbocyclic based Complex synthesized under acid environment demonstrating potential characteristic as anticancer cell.",

keywords = "Anticancer Compound, BSL Test, Co (II) Complexes, Dipicolinate Ligand, Polymer Complexes, Toxicity Test",

author = "Fahimah Martak and Endah Mutiara and Mahbub Alwathoni and Triyanda Gunawan and Soegeng Soegijanto",

year = "2021",

month = jul,

day = "1",

doi = "10.31788/RJC.2021.1435823",

language = "English",

volume = "14",

pages = "1629--1634",

journal = "Rasayan Journal of Chemistry",

issn = "0974-1496",

publisher = "Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma",

number = "3",

}

TY - JOUR

T1 - Synthesis and characterization of co (Ii) pyridine-2,6-dicarboxylate complexes as anticancer compound

AU - Martak, Fahimah

AU - Mutiara, Endah

AU - Alwathoni, Mahbub

AU - Gunawan, Triyanda

AU - Soegijanto, Soegeng

PY - 2021/7/1

Y1 - 2021/7/1

N2 - In this study, two cobalt [Co(II)] Complexes were synthesized using picolinic acid (2-pyridine carbocyclic) ligand under various pH conditions. Both Complexes were characterized using FTIR, UV-Vis, XRD, CHNS microanalysis, and thermogravimetric analysis (TGA). The Complex synthesized using metal ion: ligand mol ratio of 1:1 under pH ~2 has a molecular formula of [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O. On the other hand, the Complex synthesized using the higher ligand to metal ratio of 2 at pH ~1 has a molecular formula of [CoII (H2dipic)-(dipic)].3H2O. The [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O Complex demonstrating toxicity toward Artemia salina larvae (BSL) with the LC50 value of 5.38 ppm. Meanwhile, the [CoII (H2dipic)-(dipic)].3H2O possess an LC50 value of 8.61 ppm against the same larvae. Results showed that the Co (II)-2 Pyridine carbocyclic based Complex synthesized under acid environment demonstrating potential characteristic as anticancer cell.

AB - In this study, two cobalt [Co(II)] Complexes were synthesized using picolinic acid (2-pyridine carbocyclic) ligand under various pH conditions. Both Complexes were characterized using FTIR, UV-Vis, XRD, CHNS microanalysis, and thermogravimetric analysis (TGA). The Complex synthesized using metal ion: ligand mol ratio of 1:1 under pH ~2 has a molecular formula of [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O. On the other hand, the Complex synthesized using the higher ligand to metal ratio of 2 at pH ~1 has a molecular formula of [CoII (H2dipic)-(dipic)].3H2O. The [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O Complex demonstrating toxicity toward Artemia salina larvae (BSL) with the LC50 value of 5.38 ppm. Meanwhile, the [CoII (H2dipic)-(dipic)].3H2O possess an LC50 value of 8.61 ppm against the same larvae. Results showed that the Co (II)-2 Pyridine carbocyclic based Complex synthesized under acid environment demonstrating potential characteristic as anticancer cell.

KW - Anticancer Compound

KW - BSL Test

KW - Co (II) Complexes

KW - Dipicolinate Ligand

KW - Polymer Complexes

KW - Toxicity Test

UR - https://www.scopus.com/pages/publications/85111130603

U2 - 10.31788/RJC.2021.1435823

DO - 10.31788/RJC.2021.1435823

M3 - Article

AN - SCOPUS:85111130603

SN - 0974-1496

VL - 14

SP - 1629

EP - 1634

JO - Rasayan Journal of Chemistry

JF - Rasayan Journal of Chemistry

IS - 3

ER -

Synthesis and characterization of co (Ii) pyridine-2,6-dicarboxylate complexes as anticancer compound

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