Synthesis and Characterization of Ordered Mesoporous Carbon CMK-3 with a High Loading Capacity of Ibuprofen and its Release Performance at Simulated Body Fluid

In this paper, ordered mesoporous carbon CMK-3 have been synthesized via hard templating methode using mesoporous silica as template followed by thermal carbonization. The resulting ordered mesoporous carbon sample have been loaded by ibuprofen as anti inflammantory drug model up to 75% (w/w). Characterization of textural and structural resulting ordered mesoporous carbon was examined by transmission electron microscopy, small angle X-ray scattering, Fourier transform infrared spectroscopy and nitrogen adsorption-desorption. The high loading ibuprofen effect in release performance have been reviewed and it appears that ibuprofen loading on ordered mesoporous carbon surface can be release up to 50% in simulated body fluid at pH 7.4 for 200 min. Result shows that high ibuprofen loading not only change the textural and structural material but also have great impact for release performance. Key Word: Ordered mesoporous carbon, CMK-3, ibuprofen, high loading, release.