Synthesis and cytotoxicity of indolin-2-one derivatives against WiDr cells

Arif Fadlan; Budi Prayitno; Muhammad R.G. Fahmi; Mardi Santoso

doi:10.1063/5.0051756

Synthesis and cytotoxicity of indolin-2-one derivatives against WiDr cells

Arif Fadlan
, Budi Prayitno
, Muhammad R.G. Fahmi
, Mardi Santoso^*

^*Corresponding author for this work

Institut Teknologi Sepuluh Nopember

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

The synthesis of indolin-2-one derivatives and in vitro anticancer activity on colon cancer were reported in the present study. The compounds contain a fluorine or a bromine in position 5, and a bromine in position 7. The results established that indolin-2-one with bromine in position 5 gave up to a 4-fold improved cytotoxicity over indolin-2-one with fluorine in position 5. The indolein-2-one with bromine in posititon 5 also exerted higher cytotoxicity compared to bromine in position 7. This work highlights the importance of halogen and their position in cytotoxicity.

Original language	English
Title of host publication	4th International Seminar on Chemistry
Editors	Yuly Kusumawati, Adi Setyo Purnomo
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735441002
DOIs	https://doi.org/10.1063/5.0051756
Publication status	Published - 24 Jun 2021
Event	4th International Seminar on Chemistry, ISoC 2021 - Surabaya, Indonesia Duration: 7 Oct 2020 → 8 Oct 2020

Publication series

Name	AIP Conference Proceedings
Volume	2349
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	4th International Seminar on Chemistry, ISoC 2021
Country/Territory	Indonesia
City	Surabaya
Period	7/10/20 → 8/10/20

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1063/5.0051756

Cite this

@inproceedings{cf66df93d4ef4300ab68ecfe5592e80d,

title = "Synthesis and cytotoxicity of indolin-2-one derivatives against WiDr cells",

abstract = "The synthesis of indolin-2-one derivatives and in vitro anticancer activity on colon cancer were reported in the present study. The compounds contain a fluorine or a bromine in position 5, and a bromine in position 7. The results established that indolin-2-one with bromine in position 5 gave up to a 4-fold improved cytotoxicity over indolin-2-one with fluorine in position 5. The indolein-2-one with bromine in posititon 5 also exerted higher cytotoxicity compared to bromine in position 7. This work highlights the importance of halogen and their position in cytotoxicity.",

author = "Arif Fadlan and Budi Prayitno and Fahmi, \{Muhammad R.G.\} and Mardi Santoso",

note = "Publisher Copyright: {\textcopyright} 2021 Author(s).; 4th International Seminar on Chemistry, ISoC 2021 ; Conference date: 07-10-2020 Through 08-10-2020",

year = "2021",

month = jun,

day = "24",

doi = "10.1063/5.0051756",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Yuly Kusumawati and Purnomo, \{Adi Setyo\}",

booktitle = "4th International Seminar on Chemistry",

}

Fadlan, A, Prayitno, B, Fahmi, MRG & Santoso, M 2021, Synthesis and cytotoxicity of indolin-2-one derivatives against WiDr cells. in Y Kusumawati & AS Purnomo (eds), 4th International Seminar on Chemistry., 020060, AIP Conference Proceedings, vol. 2349, American Institute of Physics Inc., 4th International Seminar on Chemistry, ISoC 2021, Surabaya, Indonesia, 7/10/20. https://doi.org/10.1063/5.0051756

Synthesis and cytotoxicity of indolin-2-one derivatives against WiDr cells. / Fadlan, Arif; Prayitno, Budi; Fahmi, Muhammad R.G. et al.
4th International Seminar on Chemistry. ed. / Yuly Kusumawati; Adi Setyo Purnomo. American Institute of Physics Inc., 2021. 020060 (AIP Conference Proceedings; Vol. 2349).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Synthesis and cytotoxicity of indolin-2-one derivatives against WiDr cells

AU - Fadlan, Arif

AU - Prayitno, Budi

AU - Fahmi, Muhammad R.G.

AU - Santoso, Mardi

PY - 2021/6/24

Y1 - 2021/6/24

N2 - The synthesis of indolin-2-one derivatives and in vitro anticancer activity on colon cancer were reported in the present study. The compounds contain a fluorine or a bromine in position 5, and a bromine in position 7. The results established that indolin-2-one with bromine in position 5 gave up to a 4-fold improved cytotoxicity over indolin-2-one with fluorine in position 5. The indolein-2-one with bromine in posititon 5 also exerted higher cytotoxicity compared to bromine in position 7. This work highlights the importance of halogen and their position in cytotoxicity.

AB - The synthesis of indolin-2-one derivatives and in vitro anticancer activity on colon cancer were reported in the present study. The compounds contain a fluorine or a bromine in position 5, and a bromine in position 7. The results established that indolin-2-one with bromine in position 5 gave up to a 4-fold improved cytotoxicity over indolin-2-one with fluorine in position 5. The indolein-2-one with bromine in posititon 5 also exerted higher cytotoxicity compared to bromine in position 7. This work highlights the importance of halogen and their position in cytotoxicity.

UR - https://www.scopus.com/pages/publications/85125153431

U2 - 10.1063/5.0051756

DO - 10.1063/5.0051756

M3 - Conference contribution

AN - SCOPUS:85125153431

T3 - AIP Conference Proceedings

BT - 4th International Seminar on Chemistry

A2 - Kusumawati, Yuly

A2 - Purnomo, Adi Setyo

PB - American Institute of Physics Inc.

T2 - 4th International Seminar on Chemistry, ISoC 2021

Y2 - 7 October 2020 through 8 October 2020

ER -

Synthesis and cytotoxicity of indolin-2-one derivatives against WiDr cells

Abstract

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