Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line

Mardi Santoso; Arif Fadlan; Muhammad Riza Ghulam Fahmi; Ardhana Rahmayanti

doi:10.1515/chem-2021-0023

Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line

Mardi Santoso^*, Arif Fadlan, Muhammad Riza Ghulam Fahmi, Ardhana Rahmayanti

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5-8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 μM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.

Original language	English
Pages (from-to)	199-204
Number of pages	6
Journal	Open Chemistry
Volume	19
Issue number	1
DOIs	https://doi.org/10.1515/chem-2021-0023
Publication status	Published - 1 Jan 2021

Keywords

HepG2 cell line
anticancer
isatin
isatin-pyrrole derivatives

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10.1515/chem-2021-0023

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title = "Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line",

abstract = "This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5-8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 μM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.",

keywords = "HepG2 cell line, anticancer, isatin, isatin-pyrrole derivatives",

author = "Mardi Santoso and Arif Fadlan and Fahmi, {Muhammad Riza Ghulam} and Ardhana Rahmayanti",

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AU - Santoso, Mardi

AU - Fadlan, Arif

AU - Fahmi, Muhammad Riza Ghulam

AU - Rahmayanti, Ardhana

PY - 2021/1/1

Y1 - 2021/1/1

N2 - This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5-8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 μM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.

AB - This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5-8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 μM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.

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KW - isatin

KW - isatin-pyrrole derivatives

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EP - 204

JO - Open Chemistry

JF - Open Chemistry

IS - 1

ER -

Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line

Abstract

Keywords

UN SDGs

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