TY - JOUR
T1 - Synthesis of 3,3-di(1-(2-phenylbenzyl)indole-3-yl)-5-bromoindoline-2-one
AU - Titisari, Dyah Ayu
AU - Santoso, Eko
AU - Santoso, Mardi
N1 - Publisher Copyright:
© 2022
PY - 2022
Y1 - 2022
N2 - 3,3-Di(indol-3-yl)indoline-2-one (1a) was firstly isolated from the culture of a bacterium of Vibrio sp., which was separated from marine sponge Hyrtios altum. This natural microbial product exhibited various bioactivities for examples antimicrobial, antifungal, anticonvulsant, anticancer, antidiabetic. Herewith we report synthesis of 3,3-di(1-(2-phenylbenzyl)indol-3-yl)-5-bromoindoline-2-one (3) as a new analogue of 3,3-di(indol-3-yl)indoline-2-one (1a). N-Alkylation of indole gave 1-(2-phenylbenzyl)indole (4), which on treatment with 5-bromoisatin under acidic condition afforded 3,3’-di(1-(2-phenylbenzyl)indol-3-yl)-5-bromoindoline-2-one (3). Structure of compound (3) was established by NMR and high-resolution mass spectroscopies.
AB - 3,3-Di(indol-3-yl)indoline-2-one (1a) was firstly isolated from the culture of a bacterium of Vibrio sp., which was separated from marine sponge Hyrtios altum. This natural microbial product exhibited various bioactivities for examples antimicrobial, antifungal, anticonvulsant, anticancer, antidiabetic. Herewith we report synthesis of 3,3-di(1-(2-phenylbenzyl)indol-3-yl)-5-bromoindoline-2-one (3) as a new analogue of 3,3-di(indol-3-yl)indoline-2-one (1a). N-Alkylation of indole gave 1-(2-phenylbenzyl)indole (4), which on treatment with 5-bromoisatin under acidic condition afforded 3,3’-di(1-(2-phenylbenzyl)indol-3-yl)-5-bromoindoline-2-one (3). Structure of compound (3) was established by NMR and high-resolution mass spectroscopies.
KW - 3,3-di(indol-3-yl)indoline-2-one
KW - Synthesis
KW - analogue
UR - http://www.scopus.com/inward/record.url?scp=85131322500&partnerID=8YFLogxK
U2 - 10.48317/IMIST.PRSM/morjchem-v10i2.32646
DO - 10.48317/IMIST.PRSM/morjchem-v10i2.32646
M3 - Article
AN - SCOPUS:85131322500
SN - 2351-812X
VL - 10
SP - 320
EP - 325
JO - Moroccan Journal of Chemistry
JF - Moroccan Journal of Chemistry
IS - 2
ER -