Synthesis of a Microemulsion Drug Delivery System of Simvastatin and ?-oryzanol for Hypercholesterolemia

Afifatul Jannah*, Siti Zullaikah, Emeraldy Virgha Aditya, Muhammad Fadil

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Statin drugs are generally used to inhibit the formation of low-density lipoprotein (LDL), one of which is simvastatin. ?-Oryzanol is one of the natural products that can be used to lower LDL levels and increase high-density lipoprotein (HDL), in addition to focusing on simvastatin. However, simvastatin and ?-oryzanol have low bioavailability due to their low water solubility when taken orally. An oil-in-water (O/W) microemulsion system can increase the solubility of drugs in water, where the drug dissolved in the oil phase will form a microemulsion so that the bioavailability of the drug will increase. In this study, the effect of the mass ratio of a mixture of surfactant (tween 80) and cosurfactant (propylene glycol), called Smix, and demineralized water on the characteristics of the microemulsion product will be investigated. Based on the stability and drug compatibility parameters, namely transmittance, zeta potential, viscosity, droplet size, pH, conductivity, and phase separation, a formulation with a mass ratio of oleic acid: demineralized water: Smix 1:2:8 was selected. The selected formula revealed that simvastatin and ?-oryzanol solubility increased to 6.674 mg/mL and 6.064 mg/mL, respectively.

Original languageEnglish
Article number090001
JournalAIP Conference Proceedings
Issue number1
Publication statusPublished - 7 Mar 2024
Event15th Asian Congress on Biotechnology in conjunction with the 7th International Symposium on Biomedical Engineering, ACB-ISBE 2022 - Bali, Indonesia
Duration: 2 Oct 20226 Oct 2022


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