TY - JOUR
T1 - Synthesis of a Microemulsion Drug Delivery System of Simvastatin and ?-oryzanol for Hypercholesterolemia
AU - Jannah, Afifatul
AU - Zullaikah, Siti
AU - Aditya, Emeraldy Virgha
AU - Fadil, Muhammad
N1 - Publisher Copyright:
© 2024 American Institute of Physics Inc.. All rights reserved.
PY - 2024/3/7
Y1 - 2024/3/7
N2 - Statin drugs are generally used to inhibit the formation of low-density lipoprotein (LDL), one of which is simvastatin. ?-Oryzanol is one of the natural products that can be used to lower LDL levels and increase high-density lipoprotein (HDL), in addition to focusing on simvastatin. However, simvastatin and ?-oryzanol have low bioavailability due to their low water solubility when taken orally. An oil-in-water (O/W) microemulsion system can increase the solubility of drugs in water, where the drug dissolved in the oil phase will form a microemulsion so that the bioavailability of the drug will increase. In this study, the effect of the mass ratio of a mixture of surfactant (tween 80) and cosurfactant (propylene glycol), called Smix, and demineralized water on the characteristics of the microemulsion product will be investigated. Based on the stability and drug compatibility parameters, namely transmittance, zeta potential, viscosity, droplet size, pH, conductivity, and phase separation, a formulation with a mass ratio of oleic acid: demineralized water: Smix 1:2:8 was selected. The selected formula revealed that simvastatin and ?-oryzanol solubility increased to 6.674 mg/mL and 6.064 mg/mL, respectively.
AB - Statin drugs are generally used to inhibit the formation of low-density lipoprotein (LDL), one of which is simvastatin. ?-Oryzanol is one of the natural products that can be used to lower LDL levels and increase high-density lipoprotein (HDL), in addition to focusing on simvastatin. However, simvastatin and ?-oryzanol have low bioavailability due to their low water solubility when taken orally. An oil-in-water (O/W) microemulsion system can increase the solubility of drugs in water, where the drug dissolved in the oil phase will form a microemulsion so that the bioavailability of the drug will increase. In this study, the effect of the mass ratio of a mixture of surfactant (tween 80) and cosurfactant (propylene glycol), called Smix, and demineralized water on the characteristics of the microemulsion product will be investigated. Based on the stability and drug compatibility parameters, namely transmittance, zeta potential, viscosity, droplet size, pH, conductivity, and phase separation, a formulation with a mass ratio of oleic acid: demineralized water: Smix 1:2:8 was selected. The selected formula revealed that simvastatin and ?-oryzanol solubility increased to 6.674 mg/mL and 6.064 mg/mL, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85188421962&partnerID=8YFLogxK
U2 - 10.1063/5.0199219
DO - 10.1063/5.0199219
M3 - Conference article
AN - SCOPUS:85188421962
SN - 0094-243X
VL - 3080
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
IS - 1
M1 - 090001
T2 - 15th Asian Congress on Biotechnology in conjunction with the 7th International Symposium on Biomedical Engineering, ACB-ISBE 2022
Y2 - 2 October 2022 through 6 October 2022
ER -