TY - GEN
T1 - Synthesis of capsule from crab water soluble chitosan and alginate
AU - Ni'Mah, Yatim Lailun
AU - Pertiwi, Agustina
AU - Harmami, Harmami
AU - Ulfin, Ita
AU - Fadlan, Arif
N1 - Publisher Copyright:
© 2020 Author(s).
PY - 2020/4/21
Y1 - 2020/4/21
N2 - Capsules made from water-soluble chitosan (WSC) have been synthesized by adding of alginate. Capsules were made with variation of WSC:Alginate, i.e. 2:1, 3:1, 4:1, 5:1 and 6:1 (w/w). Chitosan used in this research was commercial chitosan from crab shell. Chitosan was depolymerized into water-soluble chitosan by hydrolysis method with H2O2. Characterizations were performed by FTIR test, weight uniformity test, swelling test, degradation test, solubility test and drug release test. FTIR spectra showed that the obtained capsule had vibration from its constituent molecules, i.e. chitosan and alginate. The results of the weight uniformity test and solubility test indicate that the capsules were obtained eligible the requirements by the Indonesian Pharmacopeia. The best of swelling degree in water and 0.1 N HCl solution was 84.45% and 262.23% respectively. The best of degradation percentage in water and 0.1 N HCl solution was 97.28% and 59.52% respectively. The best of drug release tests in water and 0.1 N HCl solution were 40 seconds and 1 minute 6 seconds respectively. Capsules that have the best physical appearance or texture and close to commercial capsules were WSC:Alginate 2:1.
AB - Capsules made from water-soluble chitosan (WSC) have been synthesized by adding of alginate. Capsules were made with variation of WSC:Alginate, i.e. 2:1, 3:1, 4:1, 5:1 and 6:1 (w/w). Chitosan used in this research was commercial chitosan from crab shell. Chitosan was depolymerized into water-soluble chitosan by hydrolysis method with H2O2. Characterizations were performed by FTIR test, weight uniformity test, swelling test, degradation test, solubility test and drug release test. FTIR spectra showed that the obtained capsule had vibration from its constituent molecules, i.e. chitosan and alginate. The results of the weight uniformity test and solubility test indicate that the capsules were obtained eligible the requirements by the Indonesian Pharmacopeia. The best of swelling degree in water and 0.1 N HCl solution was 84.45% and 262.23% respectively. The best of degradation percentage in water and 0.1 N HCl solution was 97.28% and 59.52% respectively. The best of drug release tests in water and 0.1 N HCl solution were 40 seconds and 1 minute 6 seconds respectively. Capsules that have the best physical appearance or texture and close to commercial capsules were WSC:Alginate 2:1.
UR - http://www.scopus.com/inward/record.url?scp=85101002622&partnerID=8YFLogxK
U2 - 10.1063/5.0002652
DO - 10.1063/5.0002652
M3 - Conference contribution
AN - SCOPUS:85101002622
T3 - AIP Conference Proceedings
BT - 3rd International Seminar on Chemical Education
A2 - Fatimah, Is
A2 - Muhaimin, null
A2 - Musawwa, Muhammad Miqdam
PB - American Institute of Physics Inc.
T2 - 3rd International Seminar on Chemical Education: Trends, Applications, Changes in Chemical Education for the 4.0 Industrial Revolution, ISCE 2019
Y2 - 17 September 2019
ER -