Synthesis of hemiterpene 1-bromo-3-methyl-2-butene derivatives

Devi A. Putri, Mardi Santoso*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)


Hemiterpene 1-bromo-2-methyl-2-butene (prenyl bromide) is widely used as a prenyl source for various organic synthesis. One of them is the development of synthetic fragrances for the perfume industry which is growing rapidly for daily consumption. Based on our literature study, most fragrances contain terpenes. There are two common groups of terpenes used as fragrances such as oxygenated monoterpenes and sesquiterpenes. Interestingly, hemiterpenes are potential but it is hard to isolate them from natural plant products. This research aims to synthesis hemiterpene derivatives with a very simple method. The synthesis method was conducted in two steps. The first step was prepared by acid-base reaction, followed by nucleophilic substitution of prenyl bromide. Furthermore, the hemiterpene derivative structures were confirmed by NMR and mass spectroscopy. For the result, three hemiterpene derivatives have been successfully synthesized and obtained in good yields namely prenyl cinnamate (1), prenyl methylbutyrate (2), and prenyl isobutyrate (3).

Original languageEnglish
Title of host publication4th International Seminar on Chemistry
EditorsYuly Kusumawati, Adi Setyo Purnomo
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735441002
Publication statusPublished - 24 Jun 2021
Event4th International Seminar on Chemistry, ISoC 2021 - Surabaya, Indonesia
Duration: 7 Oct 20208 Oct 2020

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Conference4th International Seminar on Chemistry, ISoC 2021


Dive into the research topics of 'Synthesis of hemiterpene 1-bromo-3-methyl-2-butene derivatives'. Together they form a unique fingerprint.

Cite this