Synthesis of multifunctional bioresponsive polymers for the management of chronic wounds

Gibson S. Nyanhongo*, Christoph Sygmund, Roland Ludwig, Endry Nugroho Prasetyo, Georg M. Guebitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Novel multifunctional bioresponsive gelatin and alginate based hydrogels with in-built antioxidant regenerating system and antimicrobial properties were successfully synthesized. These hydrogels are based on the versatile reactions catalyzed by cellobiose dehydrogenase (CDH). CDH uses cellobiose and cello-oligosacharides as electron donors to reduce oxidized phenolic antioxidants, quinones, or molecular oxygen to H2O2 (a well-known antimicrobial agent). The antioxidant regenerating system consisting of CDH and cellobiose increased the ability of catechol to quench nitric oxide (NO), superoxide (O2-) and hydroxyl radicals (OH ) in solution and when incorporated into hydrogels. The CDH loaded into the hydrogels free of oxidized phenolic antioxidants and quinones reduced molecular to H2O2 resulting in the complete inhibition of the growth of Stapylococcus aeureus, Bacillus subtilis, Pseudomonas putida, Escherichia coli and Cellulomonasmicrobium cellulans. This study therefore presents a new concept for synthesizing multifunctional bioresponsive chronic wound dressing polymers with in-built continuous antioxidant system able to continuously quench [reactive oxygen species (ROS) and reactive nitrogen species (RNOS)], and antimicrobial properties able to prevent microbial colonization of wound.

Original languageEnglish
Pages (from-to)882-891
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume101 B
Issue number5
Publication statusPublished - Jul 2013
Externally publishedYes


  • antimicrobials
  • antioxidants
  • bioreposnive polymers
  • cellobiose dehydrogenase
  • hydrogels
  • hydrogen peroxide
  • reactive oxygen species


Dive into the research topics of 'Synthesis of multifunctional bioresponsive polymers for the management of chronic wounds'. Together they form a unique fingerprint.

Cite this