Synthesis of Silver Nanoparticles Using Response Surface Methodology

N. Adibah, B. E. Firdianti, S. Suprapto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Silver nanoparticles have become a popular area of research in the field of nanotechnology due to their unique properties, including excellent antimicrobial activity. The synthesis of silver nanoparticles can be optimized using response surface methodology (RSM), which provides a systematic and efficient approach to determine the ideal process parameters for obtaining the desired nanoparticles. In this study, the Response Surface Methodology (RSM) - Faced-Centered Central Composite Design (FCCD) was utilized to optimize the synthesis conditions for the preparation of silver nanoparticles. The variables affecting the synthesis of silver nanoparticles, including precursor concentration, reducing agent concentration, and reaction time, were investigated. The synthesized silver nanoparticles obtained in this study had a size of 10.99 nm and a maximum wavelength of 450 nm. Through the resulting 3D plots, the impact and interaction between silver nitrate concentration, ascorbic acid concentration, and reaction time could be analyzed. Overall, this research provides valuable insights into the optimization of silver nanoparticle synthesis using response surface methodology, which can lead to the development of more efficient and effective methods for producing nanoparticles with desired properties.

Original languageEnglish
Article number03001
JournalJournal of Nano- and Electronic Physics
Issue number3
Publication statusPublished - 2023


  • Central composite design
  • Response surface methodology
  • Silver nanoparticles


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