In this study, we present a simple dual co-templating route for the synthesis of a unique natural silica material (UNS). A starch powder from waste rice and a gelatin powder was used to prepare UNS material as co-templating. In self-assembly of tetraethoxysilane (TEOS) process, triblock copolymer Pluronic F127 are employed as templating directing agents under acidic conditions. By using P127/starch/gelatin/silica composite directly catalyzed by HCl in the synthesis mixture, the unique natural silica material (UNS) were generated after calcination composite of starch, gelatin, F127 and source of silica in air, followed by organic removal in the common washing process. Character of the unique natural silica material (UNS) were studied by FTIR and scanning electron microscopy. The drug delivery system performance was evaluated by adsorption ibuprofen. The present dual co-templating route has the advantage of being a unique self-assembly approach due to the involving of economic and the green cotemplating as an additional organic precursor. More importantly, the unique natural silica material (UNS) can be the new potential material prepared and can offer great potentials for drug delivery system.