TEMPO-oxidized cellulose nanofiber (TOCN) decorated macroporous silica particles: Synthesis, characterization, and their application in protein adsorption

Annie M. Rahmatika, Yohsuke Goi, Takeo Kitamura, W. Widiyastuti, Takashi Ogi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Effective protein adsorption has attracted attention for broad application in the biomedical field. In this study, we introduce the synthesis of a TEMPO-oxidized cellulose nanofiber (TOCN) decorated macroporous SiO2 (TOCN@macroporous SiO2) particle and its protein adsorption performance. The TOCN@macroporous SiO2 particles have a unique cellulose nanofiber network structure on the macroporous, highly-negative zeta potential (−62 ± 2 mV) and high surface area (30.8 m2/g) for dried-state cellulose based particles. These characteristics provide sites that are rich in electrostatic interaction to exhibit an outstanding adsorption capacity of lysozyme (1865 mg/g). Furthermore, the TOCN@macroporous SiO2 particles have remarkably high reusability (>90% adsorption capacity) and good release of adsorbate (>80%) after 10 times of use. The material proposed in this paper has the potential for application in drug delivery, protein adsorption, biosensors, and other biomedical fields.

Original languageEnglish
Article number110033
JournalMaterials Science and Engineering C
Volume105
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Cellulose nanofiber (CNF)
  • Lysozyme
  • Nanostructured particle
  • Silica
  • TEMPO-oxidized cellulose nanofiber (TOCN)

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