TY - JOUR
T1 - TEMPO-oxidized cellulose nanofiber (TOCN) decorated macroporous silica particles
T2 - Synthesis, characterization, and their application in protein adsorption
AU - Rahmatika, Annie M.
AU - Goi, Yohsuke
AU - Kitamura, Takeo
AU - Widiyastuti, W.
AU - Ogi, Takashi
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/12
Y1 - 2019/12
N2 - Effective protein adsorption has attracted attention for broad application in the biomedical field. In this study, we introduce the synthesis of a TEMPO-oxidized cellulose nanofiber (TOCN) decorated macroporous SiO2 (TOCN@macroporous SiO2) particle and its protein adsorption performance. The TOCN@macroporous SiO2 particles have a unique cellulose nanofiber network structure on the macroporous, highly-negative zeta potential (−62 ± 2 mV) and high surface area (30.8 m2/g) for dried-state cellulose based particles. These characteristics provide sites that are rich in electrostatic interaction to exhibit an outstanding adsorption capacity of lysozyme (1865 mg/g). Furthermore, the TOCN@macroporous SiO2 particles have remarkably high reusability (>90% adsorption capacity) and good release of adsorbate (>80%) after 10 times of use. The material proposed in this paper has the potential for application in drug delivery, protein adsorption, biosensors, and other biomedical fields.
AB - Effective protein adsorption has attracted attention for broad application in the biomedical field. In this study, we introduce the synthesis of a TEMPO-oxidized cellulose nanofiber (TOCN) decorated macroporous SiO2 (TOCN@macroporous SiO2) particle and its protein adsorption performance. The TOCN@macroporous SiO2 particles have a unique cellulose nanofiber network structure on the macroporous, highly-negative zeta potential (−62 ± 2 mV) and high surface area (30.8 m2/g) for dried-state cellulose based particles. These characteristics provide sites that are rich in electrostatic interaction to exhibit an outstanding adsorption capacity of lysozyme (1865 mg/g). Furthermore, the TOCN@macroporous SiO2 particles have remarkably high reusability (>90% adsorption capacity) and good release of adsorbate (>80%) after 10 times of use. The material proposed in this paper has the potential for application in drug delivery, protein adsorption, biosensors, and other biomedical fields.
KW - Cellulose nanofiber (CNF)
KW - Lysozyme
KW - Nanostructured particle
KW - Silica
KW - TEMPO-oxidized cellulose nanofiber (TOCN)
UR - http://www.scopus.com/inward/record.url?scp=85070090881&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2019.110033
DO - 10.1016/j.msec.2019.110033
M3 - Article
C2 - 31546405
AN - SCOPUS:85070090881
SN - 0928-4931
VL - 105
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 110033
ER -