TY - JOUR
T1 - Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra
AU - Sukandar, Edwin Risky
AU - Kaennakam, Sutin
AU - Rassamee, Kitiya
AU - Ersam, Taslim
AU - Siripong, Pongpun
AU - Tip-Pyang, Santi
N1 - Publisher Copyright:
© 2019 American Chemical Society and American Society of Pharmacognosy.
PY - 2019/5/24
Y1 - 2019/5/24
N2 - Nine new xanthones, tetrandraxanthones A-I (1-9), and 22 known xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC50 values in the range of 1.6-3.4 μM, while 10 and 11 were cytotoxic against the MCF-7, HeLa S3, and KB cell lines, with IC50 values of 4.3-9.0 μM.
AB - Nine new xanthones, tetrandraxanthones A-I (1-9), and 22 known xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC50 values in the range of 1.6-3.4 μM, while 10 and 11 were cytotoxic against the MCF-7, HeLa S3, and KB cell lines, with IC50 values of 4.3-9.0 μM.
UR - http://www.scopus.com/inward/record.url?scp=85066111776&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.9b00046
DO - 10.1021/acs.jnatprod.9b00046
M3 - Article
C2 - 30978023
AN - SCOPUS:85066111776
SN - 0163-3864
VL - 82
SP - 1312
EP - 1318
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -
