Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra

Edwin Risky Sukandar; Sutin Kaennakam; Kitiya Rassamee; Taslim Ersam; Pongpun Siripong; Santi Tip-Pyang

doi:10.1021/acs.jnatprod.9b00046

Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra

Edwin Risky Sukandar
, Sutin Kaennakam
, Kitiya Rassamee
, Taslim Ersam
, Pongpun Siripong
, Santi Tip-Pyang^*

^*Corresponding author for this work

Laboratory of Natural Products and Synthetic Chemistry

Chulalongkorn University
Institut Teknologi Sepuluh Nopember
National Cancer Institute Thailand

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Nine new xanthones, tetrandraxanthones A-I (1-9), and 22 known xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC₅₀ values in the range of 1.6-3.4 μM, while 10 and 11 were cytotoxic against the MCF-7, HeLa S3, and KB cell lines, with IC₅₀ values of 4.3-9.0 μM.

Original language	English
Pages (from-to)	1312-1318
Number of pages	7
Journal	Journal of Natural Products
Volume	82
Issue number	5
DOIs	https://doi.org/10.1021/acs.jnatprod.9b00046
Publication status	Published - 24 May 2019

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10.1021/acs.jnatprod.9b00046

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title = "Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra",

abstract = "Nine new xanthones, tetrandraxanthones A-I (1-9), and 22 known xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC50 values in the range of 1.6-3.4 μM, while 10 and 11 were cytotoxic against the MCF-7, HeLa S3, and KB cell lines, with IC50 values of 4.3-9.0 μM.",

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doi = "10.1021/acs.jnatprod.9b00046",

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T1 - Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra

AU - Sukandar, Edwin Risky

AU - Kaennakam, Sutin

AU - Rassamee, Kitiya

AU - Ersam, Taslim

AU - Siripong, Pongpun

AU - Tip-Pyang, Santi

PY - 2019/5/24

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N2 - Nine new xanthones, tetrandraxanthones A-I (1-9), and 22 known xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC50 values in the range of 1.6-3.4 μM, while 10 and 11 were cytotoxic against the MCF-7, HeLa S3, and KB cell lines, with IC50 values of 4.3-9.0 μM.

AB - Nine new xanthones, tetrandraxanthones A-I (1-9), and 22 known xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC50 values in the range of 1.6-3.4 μM, while 10 and 11 were cytotoxic against the MCF-7, HeLa S3, and KB cell lines, with IC50 values of 4.3-9.0 μM.

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ER -

Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra

Abstract

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