The alteration of PGC-1α expression in younger non-professional athletes with acute medium intensity exercise model

Metabolic syndrome and physical activity entail a significant correlation to the gradual augmentation of degenerative disease incidence in the global population. Currently, several approaches have been applied to prevent the progression of metabolic syndrome, including clinical drug therapy and physical training program. However, little attention has been addressed to investigate whether acute medium intensity exercise (AMIE) co-treated with middle rhythm musical exposure can affect to thermogenesis and fatty acid oxidation. To fill this void, this present study was designed by applying AMIE and music on 45 individuals, non-professional athletes to evaluate the potential inducer of thermogenic activity (PGC-1α) profile in the muscle and adipose tissue. The finding of this study showed that AMIE exposure was significantly induced by the increase of circulating PGC-1α as linear to the high-intensity exercise group. On the contrary, the expression of this transcription factor led to decreased post-AMIE-musical co-treatment. It is suggested that AMIE can induce thermogenesis in the skeletal muscle and adipose tissue by modulating oxidative phosphorylation within mitochondria. In summary, the AMIE model may provide an alternative solution to combat metabolic syndrome linked obesity through enhancing the beta-oxidation process. Thus, the expanding investigation with a large sample and long-term monitoring program is required to establish this physical training program in the population.