Aims: Tryptamine is an amine compound derived from tryptophan by decarboxylation process. This compound can be found in fermented food and beverages, and in human gut and skin as well. This study aims to investigate the effect of tryptamine, on Gram-negative bacteria, namely Escherichia coli, Serratia marcescens and Pseudomonas aeruginosa. Methodology and results: In this study, we used E. coli, S. marcescens and P. aeruginosa due to their relatively observable quorum sensing-regulated phenotype, such as motility, prodigiosin and pyocyanin sequentially. Our results showed that tryptamine started to inhibit the growth and prodigiosin production of S. marcescens at concentration 250 μg/mL, while it inhibits the growth and pyocyanin production of P. aeruginosa at concentration 250 μg/mL and 500 μg/mL, respectively. Tryptamine inhibits both the growth and motility of E. coli at concentration 100 μg/mL. Conclusion, significance and impact of study: These results suggest that tryptamine is able to inhibit the growth of E. coli, S. marcescens and P. aeruginosa at relatively high concentration, thus decreases the quorum sensing-regulated phenotypes. It implies that the growth and quorum sensing of Gram-negative bacteria most likely will not be affected by the low concentration of tryptamine that present in the gut.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalMalaysian Journal of Microbiology
Issue number3
Publication statusPublished - Jun 2021


  • Gram-negative bacteria
  • Tryptamine
  • growth
  • quorum sensing-regulated phenotype


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