The effect of water addition in inclusion formation of ketoprofen/β-cyclodextrin using supercritical CO 2

Prida Novarita Trisanti*, Sumarno

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

Ketoprofen is a 2-(3-benzolphenyl) propionic acid with anti-inflammatory, analgesic and antipyretic properties. Ketoprofen has low solubility in water thus it decreases dissolution rate inside the body. The dissolution rate can be increased by inclusion formation of ketoprofen into β-cyclodextrin cavity. There are many methods to produce inclusion complex, such as solvent evaporation, freeze drying, kneading, and supercritical fluid. In this study, we used supercritical fluid method (SC-CO 2 ) and water was added into the mixture of ketoprofen and β-cyclodextrin to help the inclusion formation. The effect of water concentration addition of inclusion process was studied in this research. Water was added by various concentration (0-80% wt) into ketoprofen/β-Cyclodextrin mixture (1:5 w/w). The operation was conducted at 50°C and 80 bars. The products were characterized by using scanning electron microscopy (SEM), differential scanning calorimetry (DCS), and dissolution rate. From characterization result, the percentage of inclusion complexes were 92.6 - 97.3%. The highest inclusion percentage was achieved with 40% water addition. From dissolution studies, shows that dissolution rate of inclusion product was higher than pure ketoprofen.

Original languageEnglish
Title of host publication11th Regional Conference on Chemical Engineering, RCChE 2018
EditorsTeguh Ariyanto, Imam Prasetyo, Rochmadi, Nur Rofiqoh Eviana Putri
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418158
DOIs
Publication statusPublished - 21 Mar 2019
Event11th Regional Conference on Chemical Engineering, RCChE 2018 - Yogyakarta, Indonesia
Duration: 7 Nov 20188 Nov 2018

Publication series

NameAIP Conference Proceedings
Volume2085
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference11th Regional Conference on Chemical Engineering, RCChE 2018
Country/TerritoryIndonesia
CityYogyakarta
Period7/11/188/11/18

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