The Fabrication of Water-Soluble Chitosan Capsule Shell Modified by Alginate and Gembili Starch (Dioscorea esculenta L)

Yatim Lailun Ni’mah, Suprapto Suprapto, Harmami, Ita Ulfin, Puput Asmaul Fauziyah

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1 Citation (Scopus)

Abstract

Capsule shells have been successfully fabricated from water-soluble chitosan (WSC) with the addition of alginate and Gembili starch. WSC was synthesized from crab shell chitosan by depolymerization reaction. The capsule shells were made with the composition of WSC: Alginate, 2:1, 3:1 and 4:1 (w/w) with and without the addition of Gembili starch. Gembili starch was added with a ratio of Alginate: Starch, 1:1 (w/w). The capsule shell properties were evaluated according to Indonesian Pharmacopoeia standard. The solubility test showed that the capsule shells were comply with the standard. The highest degrees of swelling in water and HCl 0.1 N solution were 491.93% and 410.51%, respectively. The highest degradation percentages in water and HCl 0.1 N solution were 57.80% and 21.44%, respectively. The observation of physical appearance indicated that the capsule shell with WSC: Alginate: Starch in ratio of 3:1:1 has appearance close to commercial capsule shell.

Original languageEnglish
Pages (from-to)2365-2376
Number of pages12
JournalJournal of Renewable Materials
Volume10
Issue number9
DOIs
Publication statusPublished - 2022

Keywords

  • Capsule shell
  • capsule shell degradation
  • capsule shell solubility
  • water soluble chitosan

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