The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati; Taslim Ersam; Kuniyoshi Shimizu

doi:10.1016/j.phymed.2014.11.001

The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati^*, Taslim Ersam, Kuniyoshi Shimizu

^*Corresponding author for this work

Kyushu University

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC₅₀ value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC₅₀ of 3.48 μM.

Original language	English
Pages (from-to)	49-51
Number of pages	3
Journal	Phytomedicine
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.phymed.2014.11.001
Publication status	Published - Mar 2015

Keywords

Aldose reductase
Diabetic complications
Garcinia mangostana
Mangostin
Xanthone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phymed.2014.11.001

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abstract = "We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 μM.",

keywords = "Aldose reductase, Diabetic complications, Garcinia mangostana, Mangostin, Xanthone",

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AU - Shimizu, Kuniyoshi

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AB - We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 μM.

KW - Aldose reductase

KW - Diabetic complications

KW - Garcinia mangostana

KW - Mangostin

KW - Xanthone

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The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Abstract

Keywords

UN SDGs

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