The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum

Sri Fatmawati; Kenji Kurashiki; Sayaka Takeno; Yong Ung Kim; Kuniyoshi Shimizu; Masao Sato; Katsumi Imaizumi; Kaori Takahashi; Shinji Kamiya; Shuhei Kaneko; Ryuichiro Kondo

doi:10.1002/ptr.2425

The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum

Sri Fatmawati, Kenji Kurashiki, Sayaka Takeno, Yong Ung Kim, Kuniyoshi Shimizu, Masao Sato, Katsumi Imaizumi, Kaori Takahashi, Shinji Kamiya, Shuhei Kaneko, Ryuichiro Kondo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

The human aldose reductase inhibitory effects of the methanol extracts of 17 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum on the galactitol level in the eye lens was studied in a galactosemic rat model in vivo. This mushroom significantly decreased the galactitol accumulation.

Original language	English
Pages (from-to)	28-32
Number of pages	5
Journal	Phytotherapy Research
Volume	23
Issue number	1
DOIs	https://doi.org/10.1002/ptr.2425
Publication status	Published - Jan 2009

Keywords

Aldose reductase
Diabetic complications
Ganoderma lucidum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ptr.2425

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title = "The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum",

abstract = "The human aldose reductase inhibitory effects of the methanol extracts of 17 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum on the galactitol level in the eye lens was studied in a galactosemic rat model in vivo. This mushroom significantly decreased the galactitol accumulation.",

keywords = "Aldose reductase, Diabetic complications, Ganoderma lucidum",

author = "Sri Fatmawati and Kenji Kurashiki and Sayaka Takeno and Kim, {Yong Ung} and Kuniyoshi Shimizu and Masao Sato and Katsumi Imaizumi and Kaori Takahashi and Shinji Kamiya and Shuhei Kaneko and Ryuichiro Kondo",

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AU - Fatmawati, Sri

AU - Kurashiki, Kenji

AU - Takeno, Sayaka

AU - Kim, Yong Ung

AU - Shimizu, Kuniyoshi

AU - Sato, Masao

AU - Imaizumi, Katsumi

AU - Takahashi, Kaori

AU - Kamiya, Shinji

AU - Kaneko, Shuhei

AU - Kondo, Ryuichiro

PY - 2009/1

Y1 - 2009/1

N2 - The human aldose reductase inhibitory effects of the methanol extracts of 17 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum on the galactitol level in the eye lens was studied in a galactosemic rat model in vivo. This mushroom significantly decreased the galactitol accumulation.

AB - The human aldose reductase inhibitory effects of the methanol extracts of 17 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum on the galactitol level in the eye lens was studied in a galactosemic rat model in vivo. This mushroom significantly decreased the galactitol accumulation.

KW - Aldose reductase

KW - Diabetic complications

KW - Ganoderma lucidum

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JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 1

ER -

The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum

Abstract

Keywords

UN SDGs

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