Toxicity test of mangrove epibiont sponges in Tampora Situbondo using brine shrimp lethality test (BSLT)

Edwin Setiawan*, Awik Pudji Diah Nurhayati, Nicole J. De Voogd, Amelia Trisnanda Dewi, Alkautsar Alivy, Lanny Kartikasari, Iwenda Subagio

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

Sponges are able to live in an association with mangroves as epibionts on the roots. Mangrove sponges, which are live on the more extreme environment than sponges in coral reef ecosystem produce bioactive compounds that could be distinct. These secondary metabolites can possess a cytotoxic and potentially an anticancer effect. A method to test toxicity of a natural substance that potentially content of anticancer substance is Brine Shrimp Lethality Test (BSLT) method. The purpose of this research is to investigate toxicity of bioactive compound from a crude extract of mangrove sponge as an anticancer potential with BSLT method. The results described that all crude ethanol extracts are toxic with an LC50 value of Spheciospongia inconstans, Biemna fortis, and Dysidea sp. are 85.4380 mg·L-1, 276.024 mg·L-1, and 555.689 mg·L-1. Therefore, all extracts possessing a potential anticancer effect, especially Spheciospongia inconstans, which has the highest value of toxicity. This research can be utilized as a preliminary study for further research on anticancer compound from mangrove sponges.

Original languageEnglish
Title of host publicationInventing Prosperous Future through Biological Research and Tropical Biodiversity Management
Subtitle of host publicationProceedings of the 5th International Conference on Biological Science
EditorsZuliyati Rohmah, Lisna Hidayati, Tuty Arisuryanti, Maryani, Ganies Riza Aristya
PublisherAmerican Institute of Physics Inc.
ISBN (Print)9780735417182
DOIs
Publication statusPublished - 15 Aug 2018
Event5th International Conference on Biological Science: Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management, ICBS 2017 - Yogyakarta, Indonesia
Duration: 15 Sept 201716 Sept 2017

Publication series

NameAIP Conference Proceedings
Volume2002
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Conference on Biological Science: Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management, ICBS 2017
Country/TerritoryIndonesia
CityYogyakarta
Period15/09/1716/09/17

Keywords

  • bioactive compound
  • epibiont
  • mangrove
  • sponges
  • toxicity test

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