The high demand for nickel commodities for the application of various aspects such as stainless steel, batteries, alloys, etc. It is a challenge for Indonesia to develop laterite nickel ore processing to be more optimal. One alternative technology for laterite nickel ore processing is the combination of smelting through mini blast furnace and refining through oxidation refining. The oxidation refining utilizes metal's affinity for oxygen. Oxygen flow rate is an important parameter to be studied because of the role of oxygen as a metal oxidizer. The variables of the oxygen flow rate used were 1.5, 2.0, 2.5, 3.0, and 3.5 liter/min. The oxidation refining process began with the preparation of tools and crude Fe-Ni material and its mass was calculated at 20 grams. Then, an EDX test was performed to determine the chemical composition contained in the sample and XRD to determine the compound in the sample, after which the mass balance and heat balance were calculated. The oxidation refining process was then carried out at 1550°C with an independent variable oxygen flow rate and a fixed control variable LPG flow rate of 0.06m/s. Finally, an analysis using XRD and EDX were conducted to calculate the yield. In this study, it was found that the Nickel content increased with increasing oxygen flow rate during the refining process. The highest Nickel content (36.3%) was obtained by using an oxygen rate of 3.5 liter/min. The compound formed in the oxidation refining product was FeNi (Taenite). The highest yield (89.1%) obtained when using a variable oxygen flow rate of 2.0 liter/min.