Xanthones and biphenyls from the stems of Garcinia cylindrocarpa and their cytotoxicity

Edwin Risky Sukandar; Sutin Kaennakam; Kitiya Rassamee; Pongpun Siripong; Sri Fatmawati; Taslim Ersam; Santi Tip-pyang

doi:10.1016/j.fitote.2018.08.019

Xanthones and biphenyls from the stems of Garcinia cylindrocarpa and their cytotoxicity

Edwin Risky Sukandar, Sutin Kaennakam, Kitiya Rassamee, Pongpun Siripong, Sri Fatmawati, Taslim Ersam^*, Santi Tip-pyang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Six new compounds including four new xanthones, cylindroxanthones D–G (1–4), and two new biphenyls, cylindrobiphenyls A and B (5 and 6), were isolated from the stems of Garcinia cylindrocarpa together with 28 known compounds (7–34). The structures of the new compounds were established on the basis of extensive 1D and 2D NMR and HRESIMS spectroscopic analysis. Their cytotoxicity was evaluated against five human cancer cell lines including KB, HeLa S-3, MCF-7, Hep G2, and HT-29. Compound 23 showed strong cytotoxicity against KB, HeLa S-3, MCF-7, and Hep G2 cells with IC₅₀ values in the range of 2.20–6.00 μM. Furthermore, compound 25 selectively exhibited good cytotoxicity against MCF-7 cells with IC₅₀ value of 8.77 μM, while 31 showed good cytotoxicity against HT-29 cells with IC₅₀ value of 9.18 μM.

Original language	English
Pages (from-to)	112-117
Number of pages	6
Journal	Fitoterapia
Volume	130
DOIs	https://doi.org/10.1016/j.fitote.2018.08.019
Publication status	Published - Oct 2018

Keywords

Biphenyl
Cylindrobiphenyls A and B
Cylindroxanthones D–G
Cytotoxicity
Garcinia cylindrocarpa
Xanthone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fitote.2018.08.019

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title = "Xanthones and biphenyls from the stems of Garcinia cylindrocarpa and their cytotoxicity",

abstract = "Six new compounds including four new xanthones, cylindroxanthones D–G (1–4), and two new biphenyls, cylindrobiphenyls A and B (5 and 6), were isolated from the stems of Garcinia cylindrocarpa together with 28 known compounds (7–34). The structures of the new compounds were established on the basis of extensive 1D and 2D NMR and HRESIMS spectroscopic analysis. Their cytotoxicity was evaluated against five human cancer cell lines including KB, HeLa S-3, MCF-7, Hep G2, and HT-29. Compound 23 showed strong cytotoxicity against KB, HeLa S-3, MCF-7, and Hep G2 cells with IC50 values in the range of 2.20–6.00 μM. Furthermore, compound 25 selectively exhibited good cytotoxicity against MCF-7 cells with IC50 value of 8.77 μM, while 31 showed good cytotoxicity against HT-29 cells with IC50 value of 9.18 μM.",

keywords = "Biphenyl, Cylindrobiphenyls A and B, Cylindroxanthones D–G, Cytotoxicity, Garcinia cylindrocarpa, Xanthone",

author = "Sukandar, {Edwin Risky} and Sutin Kaennakam and Kitiya Rassamee and Pongpun Siripong and Sri Fatmawati and Taslim Ersam and Santi Tip-pyang",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = oct,

doi = "10.1016/j.fitote.2018.08.019",

language = "English",

volume = "130",

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T1 - Xanthones and biphenyls from the stems of Garcinia cylindrocarpa and their cytotoxicity

AU - Sukandar, Edwin Risky

AU - Kaennakam, Sutin

AU - Rassamee, Kitiya

AU - Siripong, Pongpun

AU - Fatmawati, Sri

AU - Ersam, Taslim

AU - Tip-pyang, Santi

PY - 2018/10

Y1 - 2018/10

N2 - Six new compounds including four new xanthones, cylindroxanthones D–G (1–4), and two new biphenyls, cylindrobiphenyls A and B (5 and 6), were isolated from the stems of Garcinia cylindrocarpa together with 28 known compounds (7–34). The structures of the new compounds were established on the basis of extensive 1D and 2D NMR and HRESIMS spectroscopic analysis. Their cytotoxicity was evaluated against five human cancer cell lines including KB, HeLa S-3, MCF-7, Hep G2, and HT-29. Compound 23 showed strong cytotoxicity against KB, HeLa S-3, MCF-7, and Hep G2 cells with IC50 values in the range of 2.20–6.00 μM. Furthermore, compound 25 selectively exhibited good cytotoxicity against MCF-7 cells with IC50 value of 8.77 μM, while 31 showed good cytotoxicity against HT-29 cells with IC50 value of 9.18 μM.

AB - Six new compounds including four new xanthones, cylindroxanthones D–G (1–4), and two new biphenyls, cylindrobiphenyls A and B (5 and 6), were isolated from the stems of Garcinia cylindrocarpa together with 28 known compounds (7–34). The structures of the new compounds were established on the basis of extensive 1D and 2D NMR and HRESIMS spectroscopic analysis. Their cytotoxicity was evaluated against five human cancer cell lines including KB, HeLa S-3, MCF-7, Hep G2, and HT-29. Compound 23 showed strong cytotoxicity against KB, HeLa S-3, MCF-7, and Hep G2 cells with IC50 values in the range of 2.20–6.00 μM. Furthermore, compound 25 selectively exhibited good cytotoxicity against MCF-7 cells with IC50 value of 8.77 μM, while 31 showed good cytotoxicity against HT-29 cells with IC50 value of 9.18 μM.

KW - Biphenyl

KW - Cylindrobiphenyls A and B

KW - Cylindroxanthones D–G

KW - Cytotoxicity

KW - Garcinia cylindrocarpa

KW - Xanthone

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U2 - 10.1016/j.fitote.2018.08.019

DO - 10.1016/j.fitote.2018.08.019

M3 - Article

C2 - 30153471

AN - SCOPUS:85052438012

SN - 0367-326X

VL - 130

SP - 112

EP - 117

JO - Fitoterapia

JF - Fitoterapia

ER -

Xanthones and biphenyls from the stems of Garcinia cylindrocarpa and their cytotoxicity

Abstract

Keywords

UN SDGs

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